Cardiovascular disease atherosclerosis is interdisciplinary problem in which treatment included are: Cardiologist, paediatricrncardiologist, neurologist, diabetologist, endocrinologist, cardiac and vascular surgeons, neurosurgeon, radiologist,rnspecialist of nuclear medicine, epidemiologist, nutricionist, pathologist, biochemist, physicin and paediatricin family doctors.rnAtherosclerosis is now one of the leading causes of death in developed countries. Begins in childhood, long time withoutrndeveloping symptoms increases with age and about 50 years of age begins to seriously threaten. The most important risk factorsrnfor the development of atherosclerotic disease are: Hyperlipidemia, hypertension, smoking, diabetes, high fibrinogen, a malernsex at younger and middle age, and menopause in women taking oral contraceptives or hormone replacement therapy onlyrnwith presence of other risk factors, excessive weight, increased level of homocysteine, physical inactivity, heredity and immunernresponse in some diseases. Approximately 60-85% of obese children become obese adults, leading to earlier and more frequentrnoccurrence of chronic non-communicable diseases: hypertension, early atherosclerosis, diabetes mellitus type 2 and other.rnCardiovascular disease stays as the predominant cause of mortality and morbidity in develop countries. Primary preventionrnshould begin as early as possible, even in childhood, creating a healthy diet, no smoking, regular physical activity, which will bernable to prevent or at least slow the development of atherosclerosis. Preventive strategy of cardiovascular disease comprises thernfollow up of subjects in the major population by which we identify factors which could effect on cardiovascular risk, as well asrnthe type of strategy in promotion of cardiovascular health in years to come.