37^th World Cardiology Conference September 26-27, 2022 Rome, Italy

Biography:

Amanuel Tadelle

Jimma University, Health institute, medical faculty, biomedical sciences department

 

Abstract:

Background: Liver disease affects the electrophysiology of the heart. ECG abnormalities, especially QT interval prolongation are common in CLD. Heart rate affects QT interval, so QT interval is reported as corrected QT interval (QTc).  The mechanism of QTc interval prolongation in patients with CLD is related to dysfunction of the autonomic nervous system.

Objective: to assess QT interval prolongation among patients with chronic liver disease.

Methods: The semi-structured questionnaire, ECG machine, automatic serum analyzer, and centrifuge were data collection instruments. Serum HDL, total proteins, albumin, bilirubin, electrolytes, triglycerides, total cholesterol, and fasting glucose were measured during data collection. LDL cholesterol was calculated. Prothrombin time was measured and INR was calculated.  The severity of liver diseases was determined by the child Pugh classification (CTP score), so patients were classified by CTP score (class A, class B, or class C).

Result:  27(32.5%) were males and 56(67.5%) were females.  39 (47%) patients were in child class B and 44(53 %) patients were in child class C. But no patients were in child class A. Among all male CLD patients, 14(35.9%) were in child class B and 13(29.5%) were in child class C. Among all female patients, 25(64.1%) were in child class B and 31(70.5%) were in child class C. 52(94.5%) of the patients had QT prolongation, 49(89.1%) of the patients had QTc prolongation.  Among QT prolongation, 24(61.5%) was in Child B, 28(63.6%) was in Child C, and among QTc prolongation, 6(15.4%) was in Child B, 43(97.7%) was in Child C. The independent factors significantly associated with QT interval prolongation in this study were systolic hypotension (p=0.003) and overweight (p=0.018).

Conclusion: QT and QTc prolongation was observed. The prolongation also was increased especially when the disease is more advanced like in child C.

Keywords: CLD, Q-T interval, Child-Pugh Classification

 

Biography:

Russian New University (RosNOU), 22 Radio str., Moscow, 7-9645069550

Abstract:

Atherosclerosis, apparently, can be slowed down or stopped, but for this it is necessary to prevent periodic leakage of arterial blood through the anastomoses into the venous bed. Blood loss in the arteries occurs in stressful situations, with increases in blood pressure, usually in a sitting position. Leaks lead to a shortage of arterial blood volume in a fixed arterial volume (on average, taking into account pulsations). The venous bed overflows at the same time. With a lack of arterial blood, the total area of the endothelial lining decreases, and the thickness of the walls of the arteries is forced to expand (towards the axis of the arteries), and this naturally causes damage to the endothelium and blood suction from the main stream into the expanding walls of the arteries. Medicine has been searching for 110 years and has not found the cause, which causes some fractions of blood, mainly LDL, to penetrate deep into the walls of the arteries, get fixed there and cause inflammatory reactions. It turns out that an unknown transport of lipids inside the elastic walls of the arteries is a cyclic pressure drop at the border of the endothelium and the main arterial flow. Critical pressure drops are caused by elastic forces of the artery walls plus gravity forces for vertical arteries. Is it possible to do something now to prevent atherosclerosis? You can! It is necessary to replenish the volume of arterial blood every day, especially after forced nervous stresses. The option of replenishing arterial blood volume is daily breathing and physical exercises, a restful night's sleep, and in hospital conditions – arterial transfusions. After all, enhanced breathing exercises lead to an increase in throughput through the pulmonary circulation, which, in turn, leads to replenishment of arterial blood volume. At the same time, the spasm of the arteries is successfully removed.

Based on the new theory of atherosclerosis, the author has developed a methodology (and is ready to share it) for experimental confirmation of the origin and development of atherosclerosis in some animal species (pigeons, chickens, rabbits, etc.) The old method of feeding rabbits with fatty foods does not stand up to any criticism.

 

Biography:

Ramachandran Muthiah, Cardiologist, Zion hospital, Azhagiamandapam and Morning star hospital, Marthandam, Kanyakumari District, India. Born on 10/5/1966.. Mother Swornam, Palaninta vilai, keezhkulam -629193. landline +91 4651 203014), Father Muthiah (Enayam thoppu) and both were farmers. School education at Aanan vilai Govt high school, keezhkulam & Concordia higher secondary school, Pootteti.. Graduated MBBS (Madurai kamaraj-1988, MD 1996, DM 2003- MGR Medical university, Chennai at Tirunelveli & Madurai Govt medical colleges).Worked as medical officer in rural health services for 5 years ( keelachekkarkudi, Arryappapuram Primary health centres, ESI hospital, Singanallur) and teaching faculty in Madras. Coimbatore, kanyakumari and Thoothukudi Govt medical colleges). Published papers in Cardiosource, American College of Cardiology, Case Reports in Clinical Medicine (SCIRP) and Journal of saudi heart association.

 

Abstract:

A 46 years old female was rushed to emergency department with sudden onset of chest discomfort. Her heart rate is initially 110 bpm and later became normal and the blood pressure was in the normal range. ECG, X-Ray chest and blood chemistry were normal. Echocardiography revealed no abnormalities. After 48 hrs observation, she was subjected to Treadmill exercise test. She achieved 9.2 METS at heart rate of 175 in Bruce protocol stage 3, developed chest discomfort with sweating at peak exercise and the test was stopped. The ECG in stage 3 at peak exercise revealed rapid up- sloping of ST segment which immediately return to normal in recovery period, may be due to episodic ischemia related to tachycardia with  heart rate of more than 160 bpm. Cardiac CT angiography showed as right coronary artery is not visualized in the Right AV groove and no anomalous vessel is passing either anterior to the pulmonary artery or in between pulmonary artery and aorta. Cardiac MR Angiography revealed non visualization of the clear cut origin of Right coronary artery from the aortic root. Aortic root angio revealed non visualization of the origin of Right coronary artery. Runs of the coronary angiogram revealed retrograde filling of right coronary artery as a continuous flow from the Left circumflex coronary artery and there is a delayed filling in proximal portion of the Right coronary artery. Other views revealed that the Left circumflex coronary artery is continuing to form the Right coronary artery, a rarest coronary anomaly.

Conclusion

Isolated left single coronary artery with left circumflex coronary artery is continuing to form the right coronary artery is a rarest congenital coronary anomaly and remaining asymptomatic up to the age of 61 years is best described in this case report

Importance of research

Junctional ST depression with rapid upsloping during exercise treadmill testing at peak exercise with symptoms of angina (episodic ischemia) is of particular importance for further evaluation of coronary vasculature