41^st World Cardiology Conference

Genomics & Precision Cardiology

Genomics & Precision Cardiology represent a transformative approach to cardiovascular care, shifting from a one-size-fits-all model to personalized prevention, diagnosis, and treatment strategies based on an individual’s genetic makeup. By integrating insights from genomics, precision cardiology aims to identify genetic risks for heart diseases, guide tailored therapies, and ultimately improve patient outcomes.At the core of this field is the understanding that cardiovascular diseases (CVDs)—such as coronary artery disease, cardiomyopathies, arrhythmias, and hypertension—often have complex genetic components. These may involve single-gene (monogenic) disorders like hypertrophic cardiomyopathy or familial hypercholesterolemia, as well as polygenic influences where multiple genetic variants contribute to disease risk in combination with environmental and lifestyle factors.Genomic testing allows for early detection of inherited cardiac conditions. For example, identifying mutations in genes like MYH7, LMNA, or SCN5A can help diagnose cardiomyopathies or channelopathies even before clinical symptoms arise. This enables proactive monitoring, lifestyle adjustments, and timely interventions—potentially preventing sudden cardiac events. Family screening also becomes possible, helping identify at-risk relatives who may benefit from genetic counseling or surveillance. In precision medicine, genomic data guide treatment decisions.